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Short answer: NAD+ injections are sold for energy, focus, recovery and healthy aging, but there are no controlled trials showing those benefits from injected NAD+. Oral NAD+ precursors raise NAD+ levels in the blood and look safe in studies, yet clear health benefits have not been shown. Injected NAD+ is a compounded product, not an FDA-approved drug, and one brand was recalled in 2025 for contamination.
What NAD+ is
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It helps turn food into energy and is used by enzymes involved in DNA repair and cell signaling. Animal research linking falling NAD+ to aging is what drew the longevity industry to it. NAD+ is not a peptide, but many of the clinics in our peptide library sell it, so we cover it here.
The benefits clinics claim
Telehealth clinics and IV lounges market NAD+ for more energy, sharper focus, faster recovery from exercise, better sleep, healthier aging and, at some clinics, support during addiction recovery. Most of these claims draw on cell and animal studies or on human trials of oral NAD+ precursors, not on trials of NAD+ injections themselves.
What the human research actually shows
| Evidence | What it found |
|---|---|
| IV NAD+ pilot study (Frontiers in Aging Neuroscience, 2019) | NAD+ was infused into a vein for 6 hours. Blood levels of NAD+ and its breakdown products did not change for the first 2 hours, and extra NAD+ and methylnicotinamide later appeared in urine, suggesting the body clears it quickly. |
| Systematic review of NAD+ supplementation (Gallagher and Emmanuel, Ageing Research Reviews, February 2026, as reported by Science-Based Medicine) | Found no eligible controlled trials measuring health outcomes of intravenous, intramuscular or subcutaneous NAD+ for anti-aging or wellness. The human trials it found were of oral precursors (NR and NMN). |
| Review of NAD+-boosting supplements (Journals of Gerontology, 2023) | Oral precursors can raise NAD+ and related compounds in several tissues and appear safe and well tolerated, but whether this improves how the body works is unclear. Studies were small and varied widely in dose and length. |
| Review of NAD+ precursors in human aging (Nature Metabolism, 2025) | Human trials have shown limited efficacy so far, and consistent evidence that NAD+ falls with age in people comes from only a few studies. |
Put simply: raising NAD+ levels is achievable, but no one has yet shown in a controlled human trial that injecting NAD+ makes people more energetic, sharper or slower to age.
Subcutaneous shots: the format telehealth clinics sell
Most online clinics ship NAD+ in a vial for you to inject under the skin at home, rather than as an IV drip. Embody lists 500 mg to 1,000 mg injections, and HealthRX supplies 1,000 mg a month and lets the provider decide how to split it into doses. The 2026 review found no controlled outcome trials of subcutaneous NAD+, so the dose, frequency and benefit of these shots rest on clinical judgment rather than trial data.
Safety and quality
2025 recall: in July 2025 GenoGenix LLC of Boca Raton, Florida, recalled a lot of its NAD+ for Injection (100 mg/mL and 200 mg/mL, 10 mL multi-dose vials) for elevated endotoxin levels, a sign of bacterial contamination. The FDA classed it as a Class I recall, its most serious level, on October 21, 2025. The product had been distributed nationwide.
Science-Based Medicine also reports that the FDA has received adverse event reports after compounders used food-grade NAD+, meant for oral products, to make sterile injectables, with reactions including severe chills, shaking and vomiting. There is no FDA-approved NAD+ drug; injectable NAD+ is made by compounding pharmacies, and its status under FDA's compounding rules can change. Our peptide legal status tracker follows changes.
Before you start, ask the clinic:
- Which pharmacy compounds the NAD+, and whether it is a 503A or 503B facility.
- Whether each batch is tested for sterility and endotoxins, and whether you can see the certificate of analysis.
- How many milligrams are in each vial and each dose, and how often you will inject.
- What to do if you have a reaction, and whether follow-ups with a clinician are included.
What NAD+ injections cost online
If you decide to try NAD+, prices vary widely. These are the listed prices on each clinic's site on October 25, 2026 (PlexusDx and Eden on October 26); several were running pre-Black Friday offers.
| Clinic | Listed price | Notes |
|---|---|---|
| CoreAge Rx | $99 a month (shown down from $199) | One 10 mL vial per order; the same $99 for its NAD+ nasal spray; multi-month plans available |
| Embody | $49 first month, then $99 a month | 500 mg to 1,000 mg injections; also advertising a pre-Black Friday discount |
| System Labs | $76 first month on the offer page we checked (shown down from $126) | System Labs runs several offer pages and prices differ between them; ongoing price not stated |
| HealthRX | $161 a month; $129 a month on a 12-month plan | 1,000 mg per month; full refund if not prescribed |
| Live Vital | $115 a month (checked October 26, 2026) | Dose set by the clinician |
| Strut Health | $149 a month | One 500 mg vial a month |
| Gala Health | From $199 per 28 days; $118 a month on a 12-month plan | Year-long commitment for the lowest price |
| PlexusDx | $159 a month; $119 a month on a 12-month plan | Same price at every dose; $139 and $129 a month on 3- and 6-month plans |
| Eden | From $91 for the first month (medication only) | 500 mg to 1,000 mg per vial; Eden’s NAD+ page also requires a membership ($39 for the first month, then $99 a month) |
Compare billing terms, supply length and milligrams, not just the headline price. Our NAD+ injection provider comparison and NAD+ nasal spray guide go into more detail.
Bottom line
NAD+ injections are an experiment, not an established treatment. The biology is real and oral precursors are being studied seriously, but there is no controlled evidence that injected NAD+ delivers the energy, focus or anti-aging benefits it is sold on. If you want to try it, choose a clinic that names its pharmacy and can show sterility and endotoxin testing, start with a single month, and judge it on how you actually feel.
Sources
- Grant R, et al. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+. Frontiers in Aging Neuroscience, 2019
- Freeberg KA, et al. Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions. Journals of Gerontology: Series A, 2023
- Vinten KT, et al. NAD+ precursor supplementation in human ageing: clinical evidence and challenges. Nature Metabolism, 2025
- Science-Based Medicine: Science vs. hype: the unproven promise of NAD+ IV therapy (July 2026)
- HMP Global: FDA issues Class I recall of NAD+ injection due to elevated endotoxin levels (October 2025)
- Embody NAD+
- HealthRX NAD+ injection
- Live Vital NAD+
- System Labs NAD+ offer
- Strut Health NAD+
- CoreAge Rx NAD+ offer
- Gala Health NAD+
- PlexusDx NAD+
- Eden NAD+
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